HematologyRoche

Roche Reports Positive COMMODORE Trial Results for Crovalimab in PNH

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Biotechnology Media Insights

Editorial Team · June 10, 2025

Roche announces positive Phase 3 COMMODORE trial results showing crovalimab non-inferior to eculizumab in paroxysmal nocturnal hemoglobinuria.

Hematology blood research laboratory with test tubes and analysis equipment

Roche today announced positive results from the Phase 3 COMMODORE trials evaluating crovalimab in patients with paroxysmal nocturnal hemoglobinuria (PNH). The trials demonstrated that crovalimab was non-inferior to eculizumab in controlling hemolysis, with a significantly more convenient subcutaneous, self-administered dosing regimen.

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