DermatologySanofi

Sanofi Reports Phase 3 PEGASUS Trial Results for Rilzabrutinib in Pemphigus Vulgaris

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Biotechnology Media Insights

Editorial Team · October 20, 2025

Sanofi announces Phase 3 PEGASUS trial results showing rilzabrutinib significantly reduces disease activity in patients with moderate-to-severe pemphigus vulgaris.

Dermatology skin treatment research with pharmaceutical laboratory equipment

Sanofi today announced results from the Phase 3 PEGASUS trial evaluating rilzabrutinib in patients with moderate-to-severe pemphigus vulgaris (PV). The trial met its primary endpoint, demonstrating a significantly higher rate of complete remission off therapy compared to placebo at week 52.

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