Eli Lilly Reports Positive Phase 3 BRUIN MCL-321 Results for Jaypirca in Mantle Cell Lymphoma
Biotechnology Media Insights
Editorial Team · September 5, 2025
Eli Lilly announces positive Phase 3 BRUIN MCL-321 trial results showing pirtobrutinib (Jaypirca) significantly improves progression-free survival in relapsed/refractory MCL.

Eli Lilly today announced positive results from the Phase 3 BRUIN MCL-321 trial evaluating Jaypirca (pirtobrutinib) in patients with relapsed or refractory mantle cell lymphoma who had received at least one prior line of therapy. The trial met its primary endpoint, demonstrating a significant improvement in progression-free survival compared to investigator's choice of therapy.
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