Peak Purity of Peptides and Large Molecules by Accurate Mass LC-MS

HRAM mass spectrometry provides an indication of peak purity and precise mass data for impurities, enabling tentative identification of co-eluting impurities invisible to UV.

Limits of UV Detection

Co-eluting impurities with similar chromophores can go undetected by UV alone.

Accurate Mass Advantage

Accurate mass data reveals impurities and supports tentative structural assignments.

Practical Use

The approach strengthens control strategies for peptides and large molecules.