NeurologySanofi
Sanofi Announces Positive Phase 3 HERCULES Trial Results for Tolebrutinib in Progressive MS
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Biotechnology Media Insights
Editorial Team · March 25, 2025
Sanofi reports positive Phase 3 HERCULES trial results showing tolebrutinib significantly slows disability progression in non-relapsing secondary progressive multiple sclerosis.

Sanofi today announced positive results from the Phase 3 HERCULES trial evaluating tolebrutinib in patients with non-relapsing secondary progressive multiple sclerosis (nrSPMS). The trial met its primary endpoint, demonstrating a 31% reduction in the risk of confirmed disability progression at 6 months compared to placebo.
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