NeurologySanofi

Sanofi Announces Positive Phase 3 HERCULES Trial Results for Tolebrutinib in Progressive MS

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Biotechnology Media Insights

Editorial Team · March 25, 2025

Sanofi reports positive Phase 3 HERCULES trial results showing tolebrutinib significantly slows disability progression in non-relapsing secondary progressive multiple sclerosis.

Neurology brain research laboratory with advanced imaging equipment

Sanofi today announced positive results from the Phase 3 HERCULES trial evaluating tolebrutinib in patients with non-relapsing secondary progressive multiple sclerosis (nrSPMS). The trial met its primary endpoint, demonstrating a 31% reduction in the risk of confirmed disability progression at 6 months compared to placebo.

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