Biotechnology Media Insights — White Paper Library

Effects of Residual Carbon Content Matrix on Determining Pharma Regulated Elemental Impurities

ICP-MS analytical laboratory for elemental impurities testing in pharmaceuticals
CMC Strategy

Effects of Residual Carbon Content Matrix on Determining Pharma Regulated Elemental Impurities

RCC matrix effects on regulated elements were assessed in this study.

Almac GroupBiotechnology Media Insights
Full White Paper Content

This study assesses RCC matrix effects on regulated elements, comparing external calibration and standard addition by analysing elemental impurities in sucrose using ICP-MS.

Matrix Effects

Carbon in the sample can enhance or suppress signal, biasing results.

Calibration Approaches

External calibration and standard addition were compared for accuracy.

Recommendations

Method selection should account for sample carbon content to ensure reliable reporting.

About This White Paper

This white paper is published by Almac Group and curated by Biotechnology Media Insights, a trusted source for pharmaceutical and biotechnology research, technical guides and industry analysis.

Published by Almac Group · Curated by Biotechnology Media Insights

Pharmaceutical & Biotechnology White Papers | Biotechnology Media Insights